Ferrous Ascorbate+Folic Acid information
Ferrous Ascorbate & Folic Acid, a synthetic form of iron and vitamin C is prescribed for pregnant women to prevent spina bifida in an unborn fetus, to improve iron utilization and to prevent folate or iron deficiency anemia.
Ferrous ascorbate is a synthetic form of iron and vitamin C. Iron is recycled by the body and produce erythroid precursor cells. Exogenous administration of folic acid is essential for normal erythropoiesis process. Folic acid is vital for the biosynthesis of purines and thymidylate of nucleic acids. Defective purine biosynthesis due to folate deficiency leads to megaloblastic anemia and macrocytic anemia.
After oral administration, the iron is predominantly absorbed in the upper jejunum and duodenum. About 90% of the administered dose is bound to plasma proteins. The iron as ferrous forms binds with transferrin and transported to the spleen, liver and bone marrow. The GI absorption of iron is very low due to systemic recycling of iron. About 1 mg/day of endogenous iron is eliminated in the urine, skin and feces.
Folic acid is rapidly absorbed in the proximal portion of the small intestine. After oral administration, the Cmax can be achieved within one hour. As tetrahydrofolic acid derivative, folic acid is well-distributed in all over the body tissues and stored in hepatic tissues. Folic acid is metabolized in liver into dihydrofolate and tetrahydrofolate forms. About 90% of the administered dose is excreted via the urine.
Ferrous ascorbate+Folic acid is contraindicated in patients with iron supplements allergy, patients with hemosiderosis, haemolytic anemia, active infections and hemochromatosis.
Other Drug Interactions
Ferrous ascorbate+Folic acid may interact with barbiturates, diphenylhydantoin, primidone, tetracycline group of drugs, quinolones, penicillamine, L-dopa, methyldopa, bisphosphonates and calcium salts.
Ferrous ascorbate+Folic acid can be taken before or after food intake
List of Contraindications
Ferrous Ascorbate+Folic Acid and Pregnancy
If taken as recommended doses, Ferrous ascorbate + Folic acid is likely safe during pregnancy.
Ferrous Ascorbate+Folic Acid and Lactation
Ferrous ascorbate + Folic acid are likely safe in lactating mothers, in recommended doses.
Ferrous Ascorbate+Folic Acid and Children
The dosage and duration should be as prescribed by a pediatrician
Each film coated tablet contains:
Ferrous ascorbate is a synthetic molecule of ascorbic acid and iron.It released in the duodenum and proximal jejunum. There is no dissociation of ferrous ascorbate on entering GI Tract due to the stable chelate of Iron with Ascorbate.
Folic acid is a B vitamin. It helps the body make healthy new cells. When a woman has enough folic acid in her body before and during pregnancy, it can prevent major birth defects of her baby`s brain or spine.
Zinc is essential for normal iron metabolism and prevention of anemia, Prevent pre-term delivery, Immunity in both mother and child, Healthy baby born ( weight balance).
This formulation is used for:
● Iron Deficiency Anemia
● During Pregnancy where the daily iron requirement may double
● Used in Inadequate Iron Intake
● Used in Growth of spurts of infants and adolescents
When ferrous ascorbate is administered it is converted to ferric form and immediately is reduced to the ferrous form into the stomach. This reduced ferrous form is then transferred to the duodenum where it is highly absorbed. And, thus has higher absorption rate respectively.
Iron chelates with tetracycline. Since oral iron products interfere with absorption of oral tetracycline antibiotics, this product should not be taken within two hours of each other. Occasional gastrointestinal discomfort may be minimized by taking with meals. Absorption of iron may be impaired by concurrent administrations of penicillamine and antacid. In patients with renal failure, a risk of zinc accumulation may exist.
Care should be taken in patients who may develop iron overload, such as those with haemochromatosis, haemolytic anemia or red cell aplasia. Failure to respond to treatment may indicate other causes of anemia and should be further investigated.
Side effects of iron, folic acid and zinc supplementation are mild and transient. These include epigastric pain, nausea, constipation, vomiting, diarrhoea, heart burn, etc.
It is contraindicated in patients with haemolytic anaemia and in conditions with increased hypersensitivity to any of its components and increased body iron content.
For faster hemoglobin rise, Minimize the risk of preterm labor, Lower the enhance of low birth weight baby, Prevent Iron Deficiency Anemia(IDA) in pregnancy
It ensures maximum iron utilization, Ensures superior absorption & better bio availability,
Folic Acid Prevents neural tube defects in pregnancy, Zinc strong antioxidant strengthens immunity.
Zinc deficiency is associated with fertility reduction, poor pregnancy outcomes , mental and behavioral change impaired immunity, increased morbidity and mortality , and perhaps linear growth retardation
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